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Giuliano Giacaglia@giu
4/10/2023

Anyone into longevity agrees/disagrees with Elon here. Why?

In reply to @giu
Snarflakes@snar
4/10/2023

Agreed, life insurance business is so big, id jump through one set of extra hoops to prove my longevity for a rate discount if it was offered. Any other extensive on going surveillance would severely cut into profit margins.

In reply to @giu
4/10/2023

Can get good looks at longevity from both of their arguments, but it’s true that people don’t look into the ones that Elon highlight as much The dietary rigor that some people put themselves through at times can be silly in comparison to stepping into a car less often in your life (chance of car accident)

In reply to @giu
CBobRobison@cr
4/10/2023

Interesting argument. Reminds me of "why do people buy real estate on the coast while believing climate change will devastate the coasts?" I've seen disease go into remission via epigenetics with staggering statistical significance, so I fundamentally disagree "it's in our genes." But I do think he has a point...

In reply to @giu
Ryan Reef@ryanreef
4/10/2023

Disagree with Elon. Elon is viewing the world through business which only captures a tiny fraction of reality.

In reply to @giu
Shane Glynn@cno
4/10/2023

If Elon’s argument was correct insurance companies wouldn’t ask if you smoke. :-) And twin studies show that BMI, smoking, alcoholism, and drug use are bigger factors than genetics in longevity. The famous Danish twin study showed the heritability of longevity to be ~0.25.

In reply to @giu
Breck Yunits@breck
4/10/2023

Agree with Elon. "Studies show" is a very weak phrase. Give me links to something showing *orders of magnitude* effects or it's probably B.S. That being said, I'm 1% open to the possibility there are vampires amongst us who have been alive for hundreds of years and do an excellent job of hiding the secret.

In reply to @giu
tim reilly@tldr
4/10/2023

I think he’s defining “genes” more on the species-level (rather than individual variation). And in this sense he’s right that if there were species-level insight into longevity there’s no way he/we could miss it. (Market forces would cause it to upturn the world like a tidal wave 🌊)

In reply to @giu
Robin A.@degenroot
4/10/2023

To some extent he is right due to genetic pre-depositions. However it is usually the environment around you and your lifestyle that triggers a genetic predisposition. *This should by no account me taken as a precise account, however in neuroscience, genetics account for 60-69% depending on a given developing disease

In reply to @giu
Devin Elliot@notdevin
4/10/2023

Both are true. I believe the fastest cars have insane horsepower I believe the fastest cars have insane torque The truth is the fastest cars have a high number of each but if you take one away the car will be below average

In reply to @giu
mk@mk
4/10/2023

Mostly disagree. IMO Elon is using an over-simplified version of genes that doesn’t account for regulation. Squirrels live about 10x as long as rats with a similar set of genes. Clean living isn’t enough, but it doesn’t take too much tweaking to get a lot more time out of the same genes.

In reply to @giu
🍍Syed Shah 🏴‍☠️🌊@syed
4/10/2023

I think it’s confusing individual level impact vs macro view. A few people start doing changes dramatically impact their life quality but it won’t show up in insurance numbers until people do it enmasse. To wait for data to show up at that level and to argue against impact until it shows up there is asinine at best

In reply to @giu
borodutch 👈👈😎@borodutch
4/10/2023

you don't have to disagree when facts are on your side it's elon who disagrees with facts this is the same mouse before and after the treatment

In reply to @giu
ted (not lasso)@ted
4/10/2023

i had no idea that we had so many geneticists and microbiologists on farcaster until this post 😜

In reply to @giu
ted (not lasso)@ted
4/10/2023

i had no idea that we had so many geneticists and molecular biologists on farcaster until this cast 😜

In reply to @giu
ted (not lasso)@ted
4/10/2023

from Nick Lane, imo the premier evolutionary epigeneticist: "Over six million years of evolution, since we split off from the apes, we have already extended our own maximum lifespan by five or six-fold, from 20 or 30 years to about 120 years... these changes were wrought by natural selection [ie genetic modification]"

In reply to @giu
Varun Srinivasan@v
4/10/2023

both statements are correct - its possible to live longer through exercise, medication, testing and treatment and you will not be able to start a life insurance company that capitalizes on that though the latter is true more for reasons of regulation, ethics and measurement challenges

In reply to @giu
mactar@mactar
4/10/2023

Sinclair is the GOAT in the field as far as I’m concerned… reminds me of Elon promoting Doge

In reply to @giu
danny iskandar@daniskandar
4/10/2023

my impression is either Elon is ignorant about longevity study or just talking pass each other. heard he is eating donut every morning, so it seems he does not believe in "Sinclair' science. If that is true, that is stupid and sad coming from him.

In reply to @giu
ProfBiceps@profbiceps
4/10/2023

Total disagree on this. I think it's best displayed in blue zones where you can see the server decay of life expectancy once they adopt western diet and lifestyle.

In reply to @giu
Pierrick@pierrick
4/10/2023

Isn’t he proving the point of the guy with his reply? Health insurance will be higher if you smoke for example.

In reply to @giu
warren@warren
4/10/2023

don’t bet against epigenetics!